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Ultra-fine bubble shower alleviates symptoms of atopic dermatitis Osaka Metropolitan University
Professor Daisuke Tsuru, Associate Professor Hisaki Imanishi, and graduate student Ayaki Matsumoto from the Department of Dermatology at Osaka Public University Graduate School of Medicine, in collaboration with Science Co., Ltd., have confirmed the efficacy of ultra-fine bubble (UFB) showers for atopic dermatitis. Atopic dermatitis is a chronic skin disease that significantly impairs quality of life due to itching and eczema, affecting many people. It is believed to be caused by genetic factors as well as environmental factors such as allergies, which can trigger or exacerbate symptoms. While drug development is progressing, there are cases where medications cannot be used due to side effect risks, and cost issues with medications also exist, making non-pharmacological methods for alleviating symptoms highly sought after. On the other hand, bathing and showering have been reported to improve skin barrier function abnormalities in atopic dermatitis. UFB, discovered in Japan, consists of bubbles with a diameter of less than 1 micrometer and is increasingly being used in showers and baths. However, its effects on skin conditions have remained unclear. In this study, we investigated the effects of UFB showers on atopic dermatitis using two mouse models: one with genetically induced atopic dermatitis and another with atopic dermatitis induced by dust mite allergens (an environmental factor). The results showed that in mice with atopic dermatitis induced by environmental factors, applying UFB showers or regular showers to the affected area for 1 minute per day over 7 to 14 days suppressed inflammation and improved skin thickness caused by inflammation. Additionally, mice exposed to UFB showers exhibited improved skin barrier function. However, no changes were observed in mice with atopic dermatitis induced by genetic factors following shower treatment. This study suggests that UFB showers may serve as a new treatment option for allergen-induced atopic dermatitis. Further studies are needed to evaluate the long-term effects of UFB shower therapy in humans.
For fixing catheters in pediatric patients who move around a lot and sweat a lot. Dressing for fixing catheter insertion sites
Nichiban Corporation will release “Catery Plus(TM) I.V. Slit for Children”, a product from the high moisture permeability film dressing “Catery Plus(TM)” series that is specialized for fixing catheter insertion sites in pediatric patients, on February 26, 2025 (manufacturer shipment).
Fukui University develops edible scaffolds for cultured meat inspired by freeze-dried tofu|Soybean-derived scaffold research is also progressing overseas
A research team from Fukui University has developed an edible porous scaffold for the mass production of cultured meat. The scaffold is based on soybeans and was inspired by the structure of traditional food, freeze-dried tofu (koya-dofu). The research results were published in the journal Food Hydrocolloids under the title “Porous edible cryogel inspired by the production of shimitofu (freeze-dried tofu) for high-density cell culture in cultured meat”. Cultured meat is attracting attention as an option for sustainable meat production, and the development of scaffolds that allow cells to grow and organize efficiently is considered important for mass production. Conventional scaffold materials often use chemical cross-linking agents, and there are issues with their edibility and safety. In cell culture, cells need sufficient interconnected space to take in oxygen and nutrients properly. In particular, the sponge-like porous structure of thick scaffold materials plays an important role in cell growth. The research team therefore focused on the production process of freeze-dried tofu.
The world's first success in fiberizing polyphenylene ether (PPE) using the melt spinning method.
Toyobo MC Co., Ltd. has established a technology for producing polyphenylene ether (PPE) fibers using the melt spinning method. This is the first time in the world that PPE fibers have been produced using this method (as of February 12, 2025, according to our research). PPE is an engineering plastic that has excellent electrical properties (insulating properties) in addition to heat resistance, flame resistance, and chemical resistance. On the other hand, because of the low fluidity of the resin when heated and melted, it was difficult to melt-mold or melt-spin PPE alone. We have now succeeded in spinning and fiberizing the resin while maintaining its fluidity by improving the melting process.
Bioabsorbable magnesium-based bulk metallic glass composite (BMGC) for improved medial opening wedge high tibial osteotomy in knee osteoarthritis
Osteoarthritis is a widespread and debilitating condition, particularly affecting the medial compartment of knee joint due to varus knee deformities. Medial opening wedge high tibial osteotomy (MOWHTO) has emerged as an effective treatment, but it comes with challenges like fractures, correction loss, and nonunion, leading to unsatisfactory results in up to 26 % of patients. In response, our study explores the potential of a bioabsorbable magnesium-based bulk metallic glass composite (Mg67Zn28Ca5 BMGC) enriched with molybdenum particles as an innovative solution for MOWHTO.
Identifying a blood biomarker that predicts the prognosis of heavy ion radiotherapy for pancreatic cancer
While heavy ion therapy for pancreatic cancer is sometimes ineffective, it has not been possible to predict prognosis as information that is useful for treatment selection. It has been found that the higher the concentration of biomarkers in the blood before heavy ion therapy, the less likely it is that distant metastasis will occur after treatment. It is hoped that this will become useful information for selecting heavy ion therapy in the future.
Duck-derived cultured cell-based food prototypes - sensory testing to assess market potential.
Integriculture has announced the successful development of prototypes using cultured cells derived from duck liver. This February, a sensory evaluation session was held at the company’s research base, the Shonan Health Innovation Park, with about 30 development personnel in attendance. Seven prototypes targeting restaurants and processed food applications were presented.
Wearable Physiological Signals under Acute Stress and Exercise Conditions
In this work, a novel dataset containing physiological signals recorded non invasevely during structured acute stress induction, as well as aerobic and anaerobic exercise sessions is presented. The physiological data were collected using the Empatica E4, a wearable device that measures electrodermal activity, skin temperature, three-axis accelerometry and blood volume pulse, from which heart rate and heart rate variability features can be derived. A stress induction protocol was designed using mathematical and emotional tasks to elicit physiological responses. For aerobic and anaerobic exercise, a stationary bike routine was developed to distinguish between the two types of activity. The dataset includes records from 36 healthy individuals during the stress protocol, 30 during aerobic exercise, and 31 during anaerobic exercise. Several machine learning algorithms were applied to validate the dataset, with XGBoost achieving an accuracy of 93% in classifying stress versus rest, 91% in distinguishing between aerobic and anaerobic exercise, and 84% in a four-label classification task involving stress, rest, aerobic, and anaerobic activities. The dataset is publicly available for further research.
Printable Molecule-Selective Nanoparticles Enable Mass Production of Wearable Biosensors
The future of medicine may very well lie in the personalization of health care—knowing exactly what an individual needs and then delivering just the right mix of nutrients, metabolites, and medications, if necessary, to stabilize and improve their condition. To make this possible, physicians first need a way to continuously measure and monitor certain biomarkers of health. To that end, a team of Caltech engineers has developed a technique for inkjet printing arrays of special nanoparticles that enables the mass production of long-lasting wearable sweat sensors. These sensors could be used to monitor a variety of biomarkers, such as vitamins, hormones, metabolites, and medications, in real time, providing patients and their physicians with the ability to continually follow changes in the levels of those molecules. Wearable biosensors that incorporate the new nanoparticles have been successfully used to monitor metabolites in patients suffering from long COVID and the levels of chemotherapy drugs in cancer patients at City of Hope in Duarte, California.
Development and Application of Breathable Haptic Textiles
Wearable haptics is a powerful medium that connects humans with VR/robots, but the issue of sweat is a challenge. When sweat and moisture accumulate on the interface, it affects the accuracy of the feedback, comfort, and hygiene.
Iceland hosts first cell-cultured shellfish tasting event outside Asia
Iceland has made history as the first location outside Asia to host a cell-cultured shellfish tasting event, showcasing innovative seafood alternatives developed by South Korean biotech firm Cellmeat in collaboration with ORF Genetics.
FMCW-based contactless heart rate monitoring
Heart disease is a significant global health issue. Traditional methods for heart rate monitoring typically require close physical contact, which limits the continuity and convenience of monitoring. To achieve real-time, non-contact heartbeat monitoring, researchers have introduced millimeter-wave radar technology. The technology’s penetration and privacy offer a potential solution for heart condition monitoring. Therefore, this study utilized frequency-modulated continuous wave (FMCW) radar for heart rate monitoring. Firstly, the collected millimeter-wave radar signals were preprocessed to accurately locate the area of cardiac activity in the human body. Secondly, an adaptive variational mode decomposition (A-VMD) algorithm was designed to extract the heartbeat signal, considering signal variations caused by random body movements and respiration and their harmonics, to obtain an accurate heartbeat signal. Finally, the accurate heart rate is obtained by weighted estimation based on the harmonic relationship of the heartbeat signal. The study invited ten subjects to participate in the experiment to verify the effectiveness of this method. The results show that this method can reduce the influence of and random body movements and respiration and harmonics on heart rate monitoring, the average absolute error of heart rate estimation is less than four bpm.
Biodegradable Microencapsulation Technology: Enhanced protection of encapsulated active ingredients while maintaining the biodegradability of the polymer
Spray-Tek has been granted a U.S. patent for its biopolymer-based core/shell microencapsulation technology. Per the company, this advancement in particle engineering offers enhanced protection for encapsulated actives, such as fragrance oils, while maintaining the biodegradability of the polymer.